Markedly reduced effects of (−)-isoprenaline but not of (−)-CGP12177 and unchanged affinity of β -blockers at Gly389-β 1 -adrenoceptors compared to Arg389-β 1 -adrenoceptors
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چکیده
منابع مشابه
Alterations in the vascular β-adrenoceptors of the rabbit knee joint due to acute inflammation
It has been shown that acute inflammation reduces the effectiveness of sympathetic nerves in the regulation of knee joint blood flow. To investigate the role of vascular β- adrenoceptors in this event, 12 NZW rabbits were maintained anaesthetized by 1 % halothane in N2O/O2, and acute knee joint inflammation was induced by intra-articular injection of 1 ml of 2% carageenan solution 24 hours be...
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The family of G-protein-coupled heptahelical receptors are widely distributed in the human body. Of special clinical importance are β-adrenoceptors, which mediate the effects of the sympathetic nervous system. In the heart, they induce, at least to a large extent, the inotropic effects of catecholamines. They confer signals from their ligands to the cell, and this signal transduction process cl...
متن کاملA Full Pharmacological Analysis of the Three Turkey β-Adrenoceptors and Comparison with the Human β-Adrenoceptors
BACKGROUND There are three turkey β-adrenoceptors: the original turkey β-adrenoceptor from erythrocytes (tβtrunc, for which the X-ray crystal structure has recently been determined), tβ3C and tβ4C-receptors. This study examined the similarities and differences between these avian receptors and mammalian receptors with regards to binding characteristics and functional high and low affinity agoni...
متن کاملThe Effect of Chronic Inflammation on Knee Joint Vascular β-adrenoceptors in Rabbit
It has been shown that inflammation reduces the effectiveness of sympathetic nerves in the regulation of knee joint blood flow, and the joint vascular- ß adrenoceptors are changed due to acute inflammation from a majority of ß-1 to an equality of ß-1 and ß-2 receptors.. To investigate the role of sympathetic nerves in nerve induced vasoconstriction and changes in joint vascular ß-adrenoceptors ...
متن کاملβ₂-adrenoceptors and muscarinic receptors mediate opposing effects on endothelin-1 expression in human lung fibroblasts.
Human lung fibroblasts are a potential source of endothelin-1 (ET-1), a pro-fibrotic mediator. The present study explored possible muscarinic and β-adrenergic modulations of ET-1 expression in human lung fibroblasts. MRC-5 human lung fibroblasts were cultured. Expression of prepro-endothelin-1 (ppET-1) mRNA was determined by quantitative real time PCR. [(3)H]-Proline incorporation was determine...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2004
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0705753